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Associate Director - Pharmacology Bioanalytical Drug Discovery Sciences

Alameda, CA, USA | Exelixis, Inc.

  • Industry:
    Pharmaceutical / Biotech
  • Position Type:
    Full-Time
  • Functions:
    Biotech/R&D/Science
  • Experience:
    5-7 years
    7-10 years
    10-12 years
Job Description:
55 people have viewed this job

Company Description


Every Exelixis employee is united in an ambitious cause: to launch innovative medicines that give patients and their families hope for the future. In this pursuit, we know our employees are our most valuable asset. After operating in the challenging biotech sector for 25 years, we have a proven track record of resiliency in the face of adversity. The success of our lead product has provided a solid commercial foundation allowing us to reinvigorate our research efforts, and grow our team in areas such as Drug Discovery, Clinical Development and Commercial.

As we expand our global partnerships and further reinvest in R&D to help us discover the next breakthrough for difficult-to-treat cancers, we’re seeking to add talented, dedicated employees to power our mission.

Cancer is our cause. Make it yours, too.


Job Description


The Associate Director, Pharmacology will utilize the newly established bioanalytical labs to develop and conduct bioanalytical assays to support pharmacokinetics and pharmacodynamics on selecting and evaluating lead small molecular compounds at pre-clinical stage. The successful candidate will also have strong knowledge and extensive experience in the development of analytical methods for the characterization of proteins and peptides (intact mass and peptide mapping) using state-of-the-art LC-HRMS instruments, including Agilent RapidFire/QTOF and Sciex UHPLC/ZenoTOF systems. This position requires collaborative interaction with various internal functional areas (including Pharmacology, PK/PD, Toxicology, Pre-formulation, MedChem and Non-clinical development) to support discovery program timelines and goals.This position will have shared responsibility for the management and development of the Pharmacology laboratory as part of the Bioanalytical team. 


Qualifications


ESSENTIAL DUTIES AND RESPONSIBILITIES: 


•Establish new bioanalytical labs; setup, maintain and troubleshoot related instruments and methods

•Plan, design, implement and analyze bioanalytical assays 

•Conduct quantitative and qualitative LC-MS/MS based bioanalysis to support in vivo PK and PD studies of small molecules

•Develop ultra-fast analytical methods using ultra high-performance liquid chromatography (UHPLC) and high-resolution mass spectrometry (HRMS) for discovery projects to analyze intact proteins, peptides, and other molecules, including small molecules, in complex matrices using state-of-the-art equipment such as Agilent RapidFire/QTOF 6545XT, Sciex UHPLC/ZenoTOF 7600, and Sciex UHPLC/QTRAP 6500+ systems

•Conduct sample analysis in various biological matrices including plasma, tumor and solid tissues to support pharmacology studies 

•Adept to automation in sample preparation and data reporting

•Develop new methodologies in conducting general research duties within assigned area of responsibility

•Prepare and organize data for presentation using analysis and visualization software, present data and reports on project status at individual, group, and departmental research meetings under general supervision

•Maintain laboratory notebook in a complete, consistent, and concise manner in accordance with company intellectual property policies and practices

•Adhere to good health and safety practices and compliance with applicable EH&S rules and participate in mandatory safety training programs


SUPERVISORY RESPONSIBILITIES:


•Supervises staff, including hiring, scheduling and assigning work, reviewing performance, and

recommends salary increases, promotions, transfers, demotions, or terminations.


EDUCATION/EXPERIENCE/KNOWLEDGE & SKILLS: 


Education:

•Bachelor’s degree in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical sciences or a closely related discipline and eleven (11) years of industry experience; or,

•Master’s degree in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical sciences or a closely related discipline and nine (9) years of industry experience; or,

•PhD in Analytical Chemistry, Chemistry, Biochemistry, Pharmaceutical sciences or a closely related discipline and five (5) years of industry experience after post-doctoral trainings; or,

•Equivalent combination of education and experience.


Experience:

•Experience in pharmaceutical development, formulation and/or analytical development

•Experience with setting up bioanalytical labs

•Prior managerial experience related to CRO personnel and in-house Bioanalytic team is required

•Direct hands-on in method development and conducting bioanalysis of small molecule using LC-MS/MS, HPLC-UV and liquid handling system is must

•Hands-on experience in protein and peptides analysis by LC/MS/MS and Q-TOF mass spectrometry for the identification and characterization of intact proteins and peptides is required

•Experience with RapidFire/QTOF 6545XT, Sciex UHPLC/ZenoTOF 7600, and Sciex UHPLC/QTRAP 6500+ systems

•Hands-on experience with analytical methodologies and equipment used to characterize test molecules 

•Ability to optimize conditions for quantitation and chromatographic separation of analyte from other detectable components in biological samples

•Adept at blood sample handling, tissue processing, and homogenization for bioanalytical assays

•Experience with MetID analyses is required


Knowledge/Skills:

•Proficiency in Sciex and Agilent LC/MS/MS instruments, ESI and APCI ionization, and QTOF mass spectrometry, as well as related software Sciex Analyst, Sciex OS, Agilent MassHunter, and Agilent Bioconfirm, is essential

•Proficiency with computer software including Phoenix 64 WinNolin, MS office, PDF, GraphPad, Chemstation, Analyst and ELN is required

•In-depth understanding of how the individual experiments fit within a larger research program to meet organizational goals

•Strong understanding and application of scientific principles, theories, and concepts in field of specialty and other related disciplines

•Excellent data analysis skills and experience with a variety of scientific software applications

•Excellent collaborative, verbal and written communication skills, problem solving, self-motivation, critical thinking, and organization skills

•Detail oriented, can multi-task and work on multiple projects concurrently. Ability to work in a fast-paced organization


WORKING CONDITIONS:


•Environment: primarily working in laboratories or in office

•Exposures encountered, such as hazardous materials

•Travel not required


Additional Information


DISCLAIMER


The preceding job description has been designed to indicate the general nature and level of work performed by employees within this classification.It is not designed to contain or be interpreted as a comprehensive inventory of all duties, responsibilities and qualifications required of employees assigned to the job.

We are an Equal Opportunity Employer and do not discriminate against any employee or applicant for employment because of race, color, sex, age, national origin, religion, sexual orientation, gender identity, status as a veteran, and basis of disability or any other federal, state or local protected class.


 


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