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Sr. Research Scientist - In Vivo Pharmacology

Santa Monica, CA, USA | Leading Pharmaceutical / Biotech Company

  • Industry:
    Pharmaceutical / Biotech
  • Position Type:
    Full-Time
  • Functions:
    Biotech/R&D/Science
  • Experience:
    7-10 years
Job Description:
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Job Description

Leading Pharmaceutical / Biotech Company is seeking an experienced Senior Scientist to lead in vivo pharmacology within the preclinical research organization in Santa Monica. The successful candidate will lead a team which supports pipeline and development programs through design and execution of in vivo studies, as well as the production and characterization of CAR T cells.  


Responsibilities and duties include, but not limited to:


Design, execute and interpret preclinical in vivo studies in support of multiple programs.

Assess activity of CAR-T cells in preclinical mouse models ex vivo through direct analysis in blood by flow cytometry, PCR or serum cytokine analysis.

Lead scale-up production of CAR-T for in vivo studies and perform in vitro characterization through the use of multiple functional assays.

Coordinate tasks across multiple projects, demonstrating prioritization and planning.

Serve as a line-function representative within a matrix organization.

Requirements:


PhD in Immunology, Molecular Biology, Cell Biology or a closely related field with a minimum 5-10 years of relevant experience (3 or more within industry).

Extensive hands-on familiarity with multi-color flow cytometry and data analysis.

Experience in the characterization of T cell function in vitro through cytotoxicity, proliferation and cytokine production assays.

Experience in the use of mouse tumor models in a variety of cancer indications.

Excellent cell culture and sterile techniques, with emphasis on primary T cell culture.

Prior experience with cell therapy and lentiviral or retroviral transgene delivery is highly desired.

Previous experience managing Research Associates and/or Scientists.

Excellent oral and written skills.

Comfortable in a fast-paced environment, able to embrace change and deploy resources to provide key deliverables.

Demonstrated leadership and the ability to collaborate with and effectively influence others.


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