Sr. Research Scientist - In Vivo Pharmacology
Santa Monica, CA, USA | Kite Pharma
Industry:Pharmaceutical / Biotech
Job Description:64 people have viewed this job
Kite Pharma is seeking an experienced Senior Scientist to lead in vivo pharmacology within the preclinical research organization in Santa Monica. The successful candidate will lead a team which supports pipeline and development programs through design and execution of in vivo studies, as well as the production and characterization of CAR T cells.
Responsibilities and duties include, but not limited to:
Design, execute and interpret preclinical in vivo studies in support of multiple programs.
Assess activity of CAR-T cells in preclinical mouse models ex vivo through direct analysis in blood by flow cytometry, PCR or serum cytokine analysis.
Lead scale-up production of CAR-T for in vivo studies and perform in vitro characterization through the use of multiple functional assays.
Coordinate tasks across multiple projects, demonstrating prioritization and planning.
Serve as a line-function representative within a matrix organization.
PhD in Immunology, Molecular Biology, Cell Biology or a closely related field with a minimum 5-10 years of relevant experience (3 or more within industry).
Extensive hands-on familiarity with multi-color flow cytometry and data analysis.
Experience in the characterization of T cell function in vitro through cytotoxicity, proliferation and cytokine production assays.
Experience in the use of mouse tumor models in a variety of cancer indications.
Excellent cell culture and sterile techniques, with emphasis on primary T cell culture.
Prior experience with cell therapy and lentiviral or retroviral transgene delivery is highly desired.
Previous experience managing Research Associates and/or Scientists.
Excellent oral and written skills.
Comfortable in a fast-paced environment, able to embrace change and deploy resources to provide key deliverables.
Demonstrated leadership and the ability to collaborate with and effectively influence others.
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